In: 80th Annual Western Veterinary Conference Notes (WVC 2008). Polyethylene glycol functions as a “penetration enhancer,” which means it increases the permeability of the skin to allow the rapid absorption of substances through the skin layer. Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects.” Source: VeterinaryNews.DVM360.com. Dogs may be attracted to ethylene glycol by its sweet taste. Polyethylene glycol 3350 may interact with other medications. The renal clearance rates of a series of polyethylene glycols ranging from 400 and 6000 molecular weights have been determined in the dogs. Another issue that polyethylene glycol has is contamination. Such drugs include certain other laxatives and stool softeners. Polyethylene glycol 3350, commonly known as MiraLAX® as well by many other trade names (see below), is used as a laxative to treat constipation for dogs and cats. Polyethylene glycol 3350 is used to stimulate bowel movements in animals with. The content on this website is not meant to replace veterinary advice. When taken internally, PEG causes the colon to absorb water and produce a watery stool. Polyethylene glycol 3350 should produce a bowel movement within 1 to 3 days of using the medication. Rita combines nature with her love for dogs by offering consulting that focuses on dogs as individuals: mind, body and spirit. Ingestion of sufficient amounts can be fatal”. HATs The unique sensitivity of cats as a species means any plan, whether short or long. Common names include Clearlax, Colyte, Dulcolax, Easylax, EZ2GO, Gavilax, Gavilyte, Gialax, Glycolax, Golytely, Healthylax, Laxaclear, Miralax, Moviprep, Natura-Lax, Nulytely, Pegylax, Powderlax, Purelax, Smooth lax, and Trilyte. In the case of our canine friends, my main concern comes with topical medication geared toward the healing of damaged skin and wounds. Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. In: 2010 ACVIM Forum Proceedings. Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects. Polyethylene glycol, more commonly known as PEG 400, is used as a plasticizer, surfactant, suppository base and ointment, solvent, and capsule and tablet lubricant in the pharmaceutical industry. Polyethylene glycol (PEG) has been widely used as colonic cleansing solution for radiological and colonoscopy procedures for many years, as well as for the treatment of constipation in humans and dogs (Belsey et al. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. Propylene glycol (PG) is one of the least toxic glycols.. Cats are particularly sensitive to PG and its use is no longer allowed in cat foods. You might be more familiar with a product called Myralax, which is sold as a laxative. MATERIALS AND METHODS Depending on the way polyethylene glycol is manufactured, PEG can contain contaminants like ethylene oxide and 1,4-dioxane. Polyethylene glycol (PEG) is a water-soluble, inactive ingredient of which only a very small amount is absorbed in the gut or gastrointestinal tract , the rest moves through the body. Cats, more than dogs, are sensitive to Propylene Glycol, especially if received in large doses over a period of time. Polyethylene Glycol 3350 (MiraLAX) for Dogs and Cats Posted by By Admin May 21, 2020 No Comments. Carr, A. Sign up for the Dogs Naturally Newsletter and get over 200 FREE Health Plans and Guides in 2020. In: AHFS drug information 2010. Polyethylene glycol 3350 is available without a prescription but should not be administered unless under the supervision and guidance of a veterinarian. It is used in many products including medications such as ointments and pills to allow them to be more easily dissolved in water. It’s actually the brand name of a medicine also known by the generic name polyethylene glycol 3350. Below 55°C it is a free flowing white powder freely soluble in water. The PEG 400, 1000, 1540 and 4000 are cleared from the plasma at a rate identical with that of creatinine in the normal, lightly anaesthetized animals (Schaffer & Critchfield, 1947). © 2020 Dogs Naturally Magazine Inc. Webster R, Didier E, Harris P, et al. It is commonly used in humans before diagnostic procedures such as colonoscopy. Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. Bethesda, MD, USA: American Society of Health-System Pharmacists; 2010. Caution: Some dogs don’t react well to PEG or polyethylene glycol (the primary active ingredient). Yes, I want to get emails from Dogs Naturally. All Rights Reserved. Propylene glycol is a colorless, odorless synthetic liquid that absorbs water. Polyethylene glycol (PEG) 3350 is not. Anaphylactic reactions to macrogol are rarely reported. Polyethylene glycol 3350, commonly known as MiraLAX® as well by many other trade names (see below), is used as a laxative to treat constipation for dogs and cats. Some pets will appear to strain which can look like constipation but is actually. From the information that I found, it would not make sense for natural product and cosmetic manufacturers to use PEG and PEG derivatives but they do. polycyclic aromatic compounds, lead, cobalt, nickel, cadmium, and arsenic. All animals are susceptible to ethylene glycol (EG) toxicity, but it is most common in dogs and cats. Symptoms of Propylene Glycol Toxicity in Dogs. Polyethylene glycol works by creating and environment where water is retained in the stool. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. You can change your mind and unsubscribe anytime. Propylene glycol poisoning in dogs is caused by ingesting propylene glycol. Polyethylene glycol 3350 belongs to the class of drugs known as osmotic laxatives. If you’d like more on how we use your information, just check out our Privacy Policy. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. Dogs rely on these bacteria for a healthy immune system and a balanced pH level. Polyethylene glycol 3350 should not be used in animals with known hypersensitivity or allergy to the drug. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. Hopefully, as more information becomes available and more people complain about the use of the ingredient, they will leave polyethylene glycol to the paint and coatings manufacturers. If you suspect your cat has symptoms of Heinz body, contact your veterinarian for testing and treatment. After we went through the usual dietary factors, we started to go over her environment and eventually her grooming products. This is most commonly seen when pets ingest liquid, high concentration propylene glycol … PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Carr A, Gaunt M. Constipation resolution with the administration of polyethylene-glycol solution in cats. While generally safe and effective when prescribed by a veterinarian, Polyethylene glycol 3350 can cause side effects in some animals. The starting dose is 1/8 to teaspoon BID, and this dose is titrated upwards depending on desired stool consistency. Her practice incorporates herbal medicine, complementary therapies and environmental stewardship to help dogs and people find balance and partnership with nature.  It is also not approved for breeding, nursing or lactating dogs or cats but is considered safe by many veterinarians. Propylene glycol is also used to make polyester compounds, and as a base for de-icing solutions. If you look at polyethylene glycol’s Material Safety Data Sheet (MSDS), under “Skin Contact” it reads: “Immediately flood affected skin with water while removing and isolating all contaminated clothing. If you need help, call us at 800.786.4751.-The Revival Education Team Was this helpful? Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. 1,4-dioxane is a chemical that remains in the environment for long periods of time because it does not easily degrade. Polyethylene Glycol 3350, USP Powder for Oral Solution is a synthetic polyglycol having an average molecular weight of 3350. Connect with Rita through her website canineherbalist.com. In dogs, the dose of Polyethylene Glycol 3350 Powder for solution varies with the size of the dog: Small dogs – 1/8 to ¼ teaspoon every 12 hours (twice daily), Medium sized dogs – ¼ to ½ teaspoon every 12 hours (twice daily), Large dogs – ½ to ¾ teaspoon every 12 hours (twice daily). Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. Full recovery is possible and often rapid in people treated with bronchoalveolar lavage. Recently, I was working with a dog who was suffering from severe itching and hair loss. Polyethylene glycol. Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG.   Medication should never be administered without first consulting your veterinarian. If the above wasn’t enough, polyethylene glycol also destroys the beneficial bacteria found on your dog’s skin and inside their stomachs. Finding out that manufacturers are using polyethylene glycol in wound care and other “natural” products sparked my interest in just how many of these products were on the market. That’s why you must base the dog’s dose on their weight (rather than what the drug’s leaflet says). Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo-controlled, randomized, blinded trials in dogs. It is commonly used in humans before diagnostic procedures such as colonoscopy. Sounds healthy, right? Polyethylene glycol 3350 is available in various solutions that have added electrolytes primarily used in humans as preparation for colonoscopy diagnostic procedures. Pelletier explained to iHeartDogs.com that propylene glycol is commonly used as a sweetener in dog products because “it’s cheap and readily available.” As mentioned in the TATSDR report, it’s also used as a preservative and to remove moisture in dry foods. As little as half a teaspoon per pound of a dog’s body weight can result in fatality. Drug Metab Dispos 2007. Please support the hard working holistic vets who make this information possible. Her diet was perfect, her home environment was as non-toxic as you can get. It and its toxic by-products first affect the central nervous system, then the heart, and finally the kidneys. How I knew that it was her post-surgical gel that was causing her itching and hair loss was that PEG causes problems with it comes in contact with broken or damaged skin. Constipation Resolution with Administration of Polyethylene-Glycol Solution in Cats (Abstract). And do dog’s like sweet? Polyethylene glycol 3350 .San Clemente, CA, USA: Medicinenet.com; 2015. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. 2012). [3, 7, 8, 10] In this paper, we present the histological evaluation of the fusion process in dogs. Sadly, most manufacturers don’t know about all the research being done into polyethylene glycol and its derivatives. Administering Miralax. 1950). Propylene glycol is a common ingredient in antifreeze, lubricants, and products of plasticity. Be certain to complete the prescription unless specifically directed by your veterinarian. A white powder for reconstitution. Route of elimination. Polyethylene glycol is a metabolically inert laxative that does not undergo intestinal enzymatic degradation or bacterial metabolism. The recommendations in this article are for the Polyethylene Glycol 3350 Powder for solution is available in either pre-measured 17 gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic names. Polyethylene Glycol 3350 (MiraLAX) for Dogs and Cats – PetPlace.  Ogbru O. Call your doctor if you are still constipated or irregular after using this medication for 7 days in a row. Gently wash all affected skin areas thoroughly with soap and water. Products include CL® Solution; CoLyte®; GoLYTELY®; NuLytely®, TriLyte®, MoviPrep®. Aspiration is an uncommon but potentially devastating complication of polyethylene glycol administration. I know you would not give Myralax to your dog but you might unknowingly give PEG to them if you are not carefully reading labels. Never exceed 3/4 teaspoon of Miralax for every 10 pounds of the dog’s body weight over a 24-hour period. PEG 3350 is an over-the-counter laxative sold using th… Las Vegas, NV, USA; 2008. Half-life. Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. To find a holistic or homeopathic vet near you or to find one who will do phone consultations, visit The Academy Of Veterinary Homeopathy. Here is the rub: Polyethylene glycol should not be in anything that you feed your dog or put on their skin, especially damaged skin. Miralax is a laxative that can primarily treat constipation in dogs. We'd love your feedback! Polyethylene glycol moderately non-toxic and its absorption into the physique is less than 0.5%. Since it has a wider margin of safety as compared to its chemical cousin, ethylene glycol, it is commonly used to absorb extra water and maintain moisture in certain medicines, cosmetics, or dog and human food products. This allows a high absorption rate of any product containing polyethylene glycol.  Tam FM, Carr AP, Myers SL. It is categorized by the FDA as a GRAS (generally recognized as safe) substance. It is also used to empty the intestines prior to diagnostic procedures. The oral LD 50 of PG in dogs is ~9 mL/kg. Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. Polyethylene Glycol 3350 Powder for the solution is available in either pre-measured 17-gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic products. PEG is non-toxic and has no effect on the body. In cats, the dose of Polyethylene Glycol 3350 Powder for the solution most commonly used is as a laxative is 1/8 to ¼ teaspoon every 12 hours on food. Minneapolis, MN, USA; 2016. Then, I came across a new wellness product she had been using that contained polyethylene glycol. There are versions of Polyethylene glycol that contain electrolytes used primarily for preparation for colonoscopy in humans including the product “Golytely®”. PEG “400” shows that the common molecular weight of the specific PEG is four hundred. However, according to Dr. Karen Becker, an integrative wellness veterinarian, propylene glycol can be toxic to dogs at certain levels. mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid “We just don’t know with specificity what those levels are,” says Becker. (www.cir-safety.org) CIR notes that PEG compounds “should not be used on damaged skin”. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. The actual molecular weight is not less than 90.0 percent and not greater than 110.0 percent of the nominal value. Somehow, the chemical has worked its way into cosmetics, canine wellness products and medicine. Seek medical attention if warranted.” Um, how can anyone think that rubbing PEG on any type of skin is a good idea after reading this warning? The product was also being sold as an “all natural” solution for wound care. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse. Polyethylene glycol (PEG) or macrogol is a polyether compound. After some research, I realized there are a large number of products containing polyethylene glycol being marketed to pets and those numbers are growing.  Paddock Laboratories, LLC. The oral LD 50 of PG in dogs is ~9 mL/kg. Polyethylene glycol 3350 normally causes loose or even watery stools. We recently showed how polyethylene glycol (PEG), a fusogen[1, 9] applied immediately on full transection of the spinal cord (so-called GEMINI protocol) can lead to motor recovery in mice, rats, and dogs. The product my client was using was for her dog’s surgical wound. She had just gotten spayed. Do not use polyethylene glycol 3350 more than once per day. American Society of Hospital Pharmacists. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Polyethylene glycol 3350. Longer-term use can cause electrolyte imbalances including high potassium and/or low sodium or cause dehydration. Following administration of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, up to 85% to 99% of the compound was excreted in the feces. Anaheim, CA, USA. PEG is manufactured for use in paints, wood treatments, detergents, cleaners and coatings. Some pets will experience lethargy, nausea, vomiting, and/or increased thirst. The National Institute for Occupational Safety and Health (www.cdc.gov/niosh) notes: “Ethylene glycol is chemically broken down in the body into toxic compounds. It is widely used as an additive in pharmaceuticals, cosmetics and food . Polyethylene glycol lavage solutions are used for colonic preparation in dogs and are considered relatively safe. Safety and palatability of polyethylene glycol 3350 as an oral laxative in cats. Rita Hogan CH is a canine herbalist and co-founder of Farm Dog Naturals, an herbal remedy company for the All-Natural Dog. Different types of macrogol exist according to their molecular weight from 300 g/mol to 10,000,000 g/mol . Tweet. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. Leib MS. Colonoscopy. The IHC Group. At 8 hours after dexamethasone administration, 18 of 18 (100%) dogs with hyperadrenocorticism given the sodium phosphate preparation and 16 of 18 (89%) affected dogs given the polyethylene glycol preparation failed to have suppression of plasma cortisol concentration (less than 1.4 micrograms/dl). [src="https://a.omappapi.com/users/3d3cb4d2c858/images/c2386e4c35af1584128187-Pet-Food-Analyzer.png"], [src="https://a.omappapi.com/users/3d3cb4d2c858/images/5a91f54387991585949493-c2386e4c35af1584128187-Pet-Food-Analyzer.png"], German Chamomile: A Bit Of Herbal Sunshine For You And Your Dog, Raw Dog Food Primer: 6 Steps To Get Started, A Veterinarian’s Journey From Kibble To Raw. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. But though it is considered generally safe for human and animal consumption, cats have a unique sensitivity to propylene glycol … 5. If cats or dogs ingest large amounts of propylene glycol, poisoning can occur.. Scary. This product touted that it quickly healed wounds and could be used as a post-surgical application to speed the healing of incisions. The Cosmetic Ingredient Review board (CIR) studies chemical compounds found in cosmetics. Propylene glycol is not as toxic as another common antifreeze ingredient known as ethylene glycol; however, it is still poisonous and dogs require medical treatment if ingested. Propylene glycol is a synthetic liquid substance that absorbs water. Cisapride is often the prokinetic of choice. Share. This quality makes the chemical extremely versatile as an additive to everything from antifreeze to food. Yes No. ©Copyright 1999 - 2020. Human formulations: There are several different trade name products for docusate. If you don’t know what something is, research it and find out if it is safe for you and your dog. How to use Polyethylene Glycol 3350 17 Gram/Dose Oral Powder. The International Agency for Research on Cancer (www.iarc.fr) has classified ethylene oxide as a known human carcinogen that can harm the nervous system and interfere with human development. I encourage you to keep reading labels and looking up ingredients. The chemical formula is HO(C2H4O)nH in which n represents the average number of oxyethylene groups. The FDA says dogs can handle small doses. The bigger GP issue is with cats. Current Veterinary Therapy XV, Bonagura and Twedt. Textbook of Veterinary Internal Medicine, Ettinger & Felman. Polyethylene glycol 3350. J Feline Med Surg 2011. Many animals will voluntarily drink ethylene glycol if antifreeze is spilled or leaks onto garage floors or driveways. Take by mouth usually once daily, or as directed by your doctor or the directions on the product package.. 1,4-dioxane is listed as a possible human carcinogen. > Propylene glycol ingested at toxic doses can cause central nervous system depression and lactic acidosis, Brutlag says. This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug. Don’t rely on the manufacturer. Here is the rub: Polyethylene glycol should not be in anything that you feed your dog or put on their skin, especially damaged skin. It is also used to empty the intestines prior to diagnostic procedures. Polyethylene glycol 3350 should not be used in animals with gastrointestinal obstructions, rectal bleeding or a tear in the intestinal wall (bowel perforation), or toxic colitis. & M. Gaunt (2010). In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. PEG can accumulate in the body if it is able to penetrate the skin layer, affecting your dog’s skin and coat, nervous system, and beneficial bacteria.  Plumb’s Veterinary Handbook by Donald C. Plumb, 9th Edition. No metabolism of PEG400 to ethylene glycol after oral administration to dogs and man could be demonstrated (determination of oxidizable substances in the plasma, Shaffer et al. 1,4. The Food and Drug Administration (FDA) has classified propylene glycol as . 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